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Clinical experience and limited human data suggest daily doses between 200-1000 g, with 500 g representing a commonly reported effective dose, though these figures lack rigorous clinical trial validation

Images were acquired by Zeiss AX10 microscope with a SPOT PURSUIT camera

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As shown in Figure 7B, the amount of p53 on Rp significantly increased by MNNG at level about 3.3-fold higher than the solvent control

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Data availability The data supporting the findings are available within the article and the associated Supplementary Data of this study