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It is also increasingly clear that addictive drugs (Koob, 1992) can hijack the reward system, a system originally evolved to motivate the drive for natural rewards

Although RSL3 and ML162 were first described as direct GPX4 inhibitors [9, 48], several publications recently challenged this notion [49, 50]

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Greenwood were supported by funds from the Leibniz Gemeinschaft, SAW-2015-IZW-1 440