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Additionally, patients with AD are particularly susceptible to developing ICD, as their preexisting skin barrier dysfunction makes them more vulnerable to exogenous irritants [30,31,32,33]

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Localized application focuses on injured areas (tendon strain, muscle tear), while systemic use supports overall recovery balance

This beneficial effect was achieved by suppressing CC-chemokine receptor 10-mediated PI3K/Akt/GSK-3/Snail signaling and preventing epithelial-mesenchymal transition