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Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]

This indicates it has potential to improve endurance across various age groups

They fucking don't

10.1016/j.neuroscience.2022.10.015 157 ZhangJ.ZhangZ.BaoJ.YuZ.CaiM.LiX.et al (2017)

Intrinsic Regulation Intrinsic Regulation receptors are subject to regulation and homeostatic control

Since B vitamins are water-soluble and easily depleted by stress, illness, diet, or certain medications, many people become deficient without realising it