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The impact of GPE on cell proliferation, migration, and survival was examined under basal conditions and in response to a wound-healing assay, relative to two other treatment groups: growth hormone (GH) and GPE + GH groups

Duan, W., Lee, J., Guo, Z

It promotes cell migration, angiogenesis, anti-inflammatory regulation, and anti-apoptotic signaling, all critical for wound repair

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113,114,115,116,117 The Aldehyde dehydrogenase 1 isoform A3 (ALDH1A3), normally not expressed in mature islets, is activated in diabetic patients, which damages characterization of cells, leads to dedifferentiation and impairs secretory function

Ipamorelin and other GHS are also less convenient than HGH therapy