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no published dose-response or dose-optimization data exists beyond the animal pharmacology

Additionally, the expression of proteins involved in the metabolism of other sugars was downregulated giving the bacteria a selective advantage for preferential utilization of simple sugars and thus to shut down the redundant metabolic processes

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44 In the 1980s, Kahn elucidated the role of insulin receptor in glucose uptake and metabolism, advancing the understanding of insulin signaling and resistance