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Mallea-Gil MS, Ballarino MC, Spiraquis A, Iriarte M, Kura M, Gimenez S, Oneto A, Guitelman M, Machado R, Miguel CM
in vitro BBB model studies have reported tobacco-induced alterations in TJ protein expression and re-distribution, which increases intracellular ROS/RNS and the secretory profile of various pro-inflammatory markers ( Direct nicotine binding to nicotinic acetylcholine receptors on BECs induces acetylcholine-dependent nitric oxide (NO) release via activation of neurovascular endothelial NO synthase ( 2 enhances vascular membrane permeability at the BBB
Chronically elevated fasting blood glucose levelsor recurrent, excessive spikes in glucose levels after meals can lead to devastating long-term consequences such as heart disease and stroke, blindness, kidney failure, neuropathy, liver disease, and even cancer (Ahmadieh 2014