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Therefore, to experimentally compare the outcomes of ABHD11 inhibition to glutarate accumulation, we used HeLa cells as a well-studied cancer cell line, alongside primary human CD8 + T lymphocytes, where the effects of DEG have been well characterized 9

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However, the NADPH-oxidase activity (which also uses NADPH as a cofactor) is increased (producing H 2 O 2 ) during active vitiligo, therefore increasing ROS and promoting an active competition with EAS enzymes for NADPH molecules, a molecule already reduced in active vitiligo patients (Shajil and Begum, 2006)