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CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality-Mediated mitochondrial dysfunction

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28 Sick day management GPs can play an important role in reinforcing the principles of sick day management, especially those related to medication use, in people with DKD

GSH is the primary intracellular antioxidant and one of the key regulatory factors in GPX4 expression 30,31 .Through restoration of SLC7A11 expression, OSR facilitated greater cystine uptake and GSH accumulation, while simultaneously lowering the levels of lipid peroxidation by-products such as MDA and 4-HNE