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Several variants in the TRPM3 gene are more often found in people with ME/CFS.[ref] NLRP3 inflammasome activation and fatigue: Another innate immune system component, the NLRP3 inflammasome, is also implicated in fatigue syndromes, including ME/CFS and MS.[ref][ref] NLRP3 is a linchpin at the start of the immune cascade

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