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Current epidemiological data indicate that over 21 million Americans are affected by age-related eye diseases, with digital device usage now averaging 7.4 hours daily among adultscreating unprecedented oxidative stress on ocular tissues

Available from: [17] Lu Q, Jiang Z, Wang Q, Hu H, Zhao G

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and another study which showed that chemotherapy and radiotherapy resistance is mediated in ovarian cancer by hypoxia-inducible factor 1 alpha (HIF-1) and IGF-1-mediated upregulation of reactive oxygen species (ROS) inducer NADPH oxidase 4 (NOX4) (26)

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Patients should be counseled to distribute fluid intake throughout the day rather than consuming large volumes at once, and to increase intake during hot weather or physical activity