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and very severe (emergency) 84 27

Whole-cell voltage-clamp recordings revealed that the amplitude of NMDA receptor-mediated tonic currents in the FG + DMV neurons were significantly decreased in the taCaspase3 group compared to control group (Supplementary Fig

This understanding has led to the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) and dual GIP/GLP-1 receptor agonists (such as tirzepatide) as pharmaceutical treatments

However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD

Tirzepatide is unique because it targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, making it a dual agonist

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