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If nausea persists beyond 3-4 weeks on a stable dose, consider reducing to the previous dose level and attempting re-escalation more gradually after 4-6 weeks

Besides, this patient had subcutaneous nodules in buttocks and thighs concurrently with one of the outbreaks of the systemic disease

Three proteins, osteopontin (OSTP), alpha-1-acid glycoprotein 1 (A1AG1), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), were previously found to be increased in the urine of IC/BPS patients relative to healthy controls 21,22

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FAK-paxillin pathway activation: This activation accelerates cell migration and fibroblast adhesion toward injured areas