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Animal studies have demonstrated a role of GLP-1 RA in ameliorating large and small fibre neuropathy through remyelination, reduction in Schwann cell apoptosis and decreasing cAMP levels, thereby augmenting the nerve sodiumpotassium pump [11, 12]

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However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease

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KPV has a simpler structure with a molecular formula of C17H26N4O4 and a molecular weight of 350.42 g/mol

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J., Li, Y., & Greig, N

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