Summary Integrating GLP-1 RA therapy with tailored resistance exercise and caloric restriction with dietary counseling, including adequate protein intake (1.21.6 g/kg/day), may help preserve muscle mass and function in older adults
Further, several VABS-II domain scores such as adaptive behavior ( p = 0.03), socialization ( p = 0.03), maladaptive behavior ( p = 0.04) and internalizing behavior ( p = 0.02) also indicated significant changes
Losing 5 to 10% of body weight, even temporarily, provides health benefits, from improved blood sugar to reduced joint strain to better sleep
Semaglutide at therapeutic doses reduces A1c by 1.0 to 1.5 percentage points on average
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Women with a history of hormone-sensitive cancers, blood clots, stroke, or certain cardiovascular conditions may be advised to avoid estrogen therapy altogether, or at least systemic MHT