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A higher mitotic rate (2 mitoses per 10 HPFs) has been noted to correlate with metastasis, but the converse is not necessarily true, and benign-looking lesions still have malignant protentional

[54] He was, however, unable to explain the reason why, and his assertion had no impact on the prevailing opinion of the influential physicians of the age, that scurvy was a digestive complaint

HT is associated with reduced expression of anti-apoptotic Bcl-2, which is normally abundant in healthy thyroid tissue(Hammond et al

Its cell-penetrating properties allow it to enter cells without transfection or vector delivery, where it directly engages the p53 TAD2 domain to disrupt the FOXO4-p53 complex

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Western blot analysis confirmed reduced levels of apoptotic markers, including Cleaved Caspase-3 (C-Caspase-3) and BAX in M9a+sh EPAS1 cells under hypoxia (Fig