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Each method targets a different depth of pigmentation: lasers break up deeper melanin, peels remove dull surface cells, and glutathione improves brightness from within

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The resulting stress may affect mitochondrial energy, antioxidant defense, neurotransmitter regulation, sleep, cognition and medication tolerance

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To further support the observations and conclusions, expression levels of the counter-selectable gene GAP1 and genes involved in GSH synthesis were determined by RT-qPCR in the pGSH1-GAP1 strain