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The rate of hypoglycemia was similar in this other insulin glargine product and NPH insulin treated patients [see Adverse Reactions (6.1)]

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In summary, UPFs may have the potential to elicit addiction-like responses through overstimulation of dopaminergic reward pathways, which may lead to a downregulation of D2 receptors

Nausea is particularly common, affecting approximately 1520% of patients, though it typically diminishes over time as tolerance develops