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One reason for the difference is that rats lack cultural inhibitions that we humans have, says Pfaus

These studies investigate various mechanisms, including altered energy metabolism (e.g., glycolysis and oxidative phosphorylation), lysosomal dysfunction, RNA toxicity, and mtDNA mutations

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doi: 10.1093/jn/138.3.439

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cGAS-STING signaling in astrocytes and CNS inflammation In astrocytes, AD model mice (5xFAD) crossed with the Cgas / line exhibited a reduction in GFAP + cell area, indicating the involvement of the cGAS-STING pathway (Xie et al., 2023)