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These findings clearly demonstrated that both seasonal and in vitro extreme temperatures significantly impaired oocyte quality and embryo production, emphasizing the need to develop strategies to reduce the impacts of heat stress and enhance reproductive outcomes in sheep
A large number of studies have investigated peripheral metabolomic changes in the aforementioned conditions, with considerable overlap between PAIS, CFS, and immunometabolic depression: As reviewed by Komaroff et al., the systemic metabolomic changes in ME/CFS patients are characterized by (1) an impairment in the production of ATP from all energy substrates, (2) a general hypometabolic state and (3) an imbalance between pro- and antioxidant metabolites favouring pro-oxidant processes [43, 62]
Cousins, J
34: 161824 Orchard TJ, Strandness DE
Targeting mitochondria as a therapeutic approach for parkinsons disease