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Pain and Discomfort : Lipedema can be associated with pain, discomfort or a feeling of heaviness in the affected areas, which can be constant or occur from time to time

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V.MontagneseP.MandileP.CotugnoM.Grassi ZucconiG.et al (1995)

In some early trials, effects like shorter sleep latency were seen fairly quickly (within hours) after administration

I asked her to list her symptoms and grade them on a scale of 1 to 10, 1 being very minor, and 10 being a very heavy or severe symptom