bariatric surgery vs glp-1 GLP-1s Vs. For Weight Loss Metabolic Bariatric Surgery vs. GLP-1

Organ growth concerns (acromegaly-like effects) are theoretically possible with chronic supraphysiological IGF-1 exposure, though no human studies document this outcome at research doses below 100 mcg daily for fewer than 12 weeks

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Grossman DC, Bibbins-Domingo K, Curry SJ, Barry MJ, Davidson KW, Doubeni CA, et al

Silva, G

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339 Additionally, PFKFB3-driven glycolysis also promotes histone Kla and boosts profibrotic gene expression in silica-treated mice, a process that can be inhibited by activating glucagon-like peptide-1 receptor (GLP-1R), disrupting the interaction between the NLRP3 inflammasome and PFKFB3, and intensifying pulmonary fibrosis progression