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Dimitrova and Aleksandrova 2021)

The compound Ras-selective lethal 3 (RSL3, Figure 2D), which can covalently bind to the selenocysteine (Sec) at the active site of GPX4 and inhibit its activity, is a highly effective ferroptosis inducer ( Gpx4 can promote ferroptosis in mouse embryonic fibroblasts, while overexpression of Gpx4 made cells more resistant to RSL3-induced ferroptosis (Yang et al., 2014)

However, the activation of microglia and astrocytes leads to the accumulation of osmolytes and increased cell size, reflecting a higher MI content [171]

Effects of IGF-1 on the cardiovascular system