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Frontiers in Pharmacology , 11 , 593832 Prakash, M

Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

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LPS activates macrophages through TLR 4, prompting the release of inflammatory factors such as IL-1 and TNF- , which drive Th 1 differentiation and promote IFN- secretion, further magnifying local inflammation in the thyroid gland (Zhang et al., 2023)