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Two observations suggested an important role for the vagus nerve: 1

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Some people notice stronger nausea when both are taken close together

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Brand-Name Comparison Brand-name Mounjaro or Zepbound: $1,069 monthly Compounded tirzepatide: $349 monthly Monthly savings: $720 (67% less expensive) 18-month treatment: Brand-name: $19,242 Compounded: $6,282 Total savings: $12,960 Semaglutide vs Tirzepatide Cost Comparison Compounded semaglutide: $199 monthly Compounded tirzepatide: $349 monthly Difference: $150 monthly more for tirzepatide The question becomes whether tirzepatides superior clinical results (22.5% average weight loss versus 14.9% for semaglutide) justify the additional $150 monthly cost