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2022 Apr;22(2):97-105

Available at: Funk AL, Lu Y, Yoshida K, Zhao T, Boucheron P, van Holten J, Chou R, Bulterys M, Shimakawa Y

Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis

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Imbalances between glutamate and GABA, which are strongly implicated in neuropsychiatric disorders like MDD [77], can lead to excitotoxicity, whereby excessive glutamate activation of NMDARs and AMPARs triggers calcium overload, oxidative stress, and cell death [78]