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Physiologically Based Pharmacokinetic (PBPK) Modeling GastroPlus (version 9.5, SimulationsPlus, Lancaster, CA, USA) was used to establish a PBPK model of M8891 using PK data from rat and dog and the compound-specific parameters, i.e

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2013;17(Suppl 1):S367-S373

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Our team advises fasting for at least two to three hours before administration