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By activating GLP-1 peptides, these medications affect body weight in many ways, including inhibiting glucagon and stimulating insulin release, and resulting in an average loss of 5% to 15% of body weight sustainable for at least 12 months

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After being on the GLP-1 for nearly a year, Don recognizes hes still not riding as well as he could if he was a lower weight without the drugs, but hes learned to make the best of the situation

He now takes naltrexone alone for its mental health benefits