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It has been suggested that secreted lysosomes may contribute to the repair of the glycocalyx on cellular membranes during cytosolization (79), but the opposite has been identified in patients with sepsis (55)

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Semaglutide enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

Until such evidence emerges, clinical use should proceed with appropriate caution and recognition of the investigational nature of this promising but unproven therapeutic peptide