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2020;105(8):e27106

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Ion pumps actively transporting ions such as H + , Na + , K + , Ca 2+ and Cu 2+ produce and maintain electrochemical ion gradients across the cellular membranes which are subsequently used by secondary active ion-coupled transporters to deliver molecules in antiport (also known as exchange) or symport (also known as co-transport) of these ions (45, 46)

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Cagrilintide also has one of the lowest GI odds ratios among the incretin and amylin compound class in a 2025 Bayesian network meta-analysis of multi-target obesity therapies the relevance for the stack is that adding cagrilintide to retatrutide may not compound GI burden as severely as adding a second GLP-1 agonist would

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Katz M, Levine AA, Kol-Degani H, Kav-Venaki L

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