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among those, GTPases or their activators/inhibitors (Tiam-1 - T-cell lymphoma invasion and metastasis-inducing protein 1, Rho-C - Ras homolog gene family, member C), and receptor tyrosine kinase (RTK) upstream of Rho GTPases as hepatocyte growth factor receptor (HGFR/c-Met) or tyrosine kinase receptor (Trk-A) [22]
Forced expression of CRAT inhibited migration and invasion of OC cells through suppression of epithelialmesenchymal transition (EMT) We also examined the functional role of CRAT in migration and invasion of OC cells
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Results: Our cohort included 2,405 patients (mean[SD] age 48[10], 53% female), with a BMI[SD] of 37[8] kg/m 2 and a mean baseline weight of 238[54] lbs
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