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Neurological symptoms are particularly characteristic and may include: Paraesthesia (pins and needles) in the hands and feet Numbness or altered sensation in the extremities Difficulty with balance and coordination, often due to spinal cord involvement (subacute combined degeneration) Memory problems and cognitive impairment Mood changes, including depression and irritability Visual disturbances (rare and usually in advanced deficiency) Haematological manifestations commonly present as symptoms of anaemia: Persistent fatigue and weakness Breathlessness, particularly on exertion Palpitations or rapid heartbeat Pale or jaundiced (yellowish) skin Glossitis (sore, red tongue) Mouth ulcers Additional signs may include: Unexplained weight loss Diarrhoea or constipation Loss of appetite Muscle weakness The severity and combination of symptoms vary considerably between individuals

Ross, D

Moreover, due to the negative consequences of excessive caffeine use and its bitter taste, a method for masking this taste and designing a controlled-release delivery system for longer durations is required

doi: 10.3389/fcimb.2021.663131 27 AndersSTanakaMKinneyDK

If an injection is given within the [global surgery period], it might not be separately billable unless it is for a completely unrelated condition