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Key Points Glutathione serves as a crucial endogenous antioxidant that plays a pivotal role in combating oxidative stress associated with dementia NAD is essential for energy metabolism and mitochondrial function, with potential implications in neurodegenerative diseases like dementia NAC acts as a precursor to glutathione synthesis and exhibits antioxidant and anti-inflammatory activities beneficial for neurodegenerative conditions IV Glutathione Studies suggest that elevating glutathione levels through IV administration may offer a therapeutic strategy to combat oxidative stress in Alzheimer's disease and mild cognitive impairment Glutathione's antioxidant properties play a significant role in protecting neurons from oxidative damage, potentially slowing disease progression IV NAD NAD levels decline with age and have been implicated in neurodegenerative diseases like dementia