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Participants on GLP-1 or GIP/GLP-1 RAs reduced caloric intake by 1639 % compared to those receiving placebo treatment [[16], [17], [18], [19],[25], [26], [27], [28], [29], [30], [31]]

However, in certain cases, they may interfere with the peptides ability to interact with its target or disrupt bioactive conformation, significantly reducing its activity 44,45

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Although individual primary studies indicated that baseline characteristics do not significantly affect the results, combining outcomes from multiple primary studies in meta-analyses could be influenced by these differences

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