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According to clinical trial data for semaglutide: nausea (up to 44% of patients) and diarrhoea (~30%) are the top complaints , followed by vomiting (~24%), constipation, and general stomach discomfort

Clinical studies suggest that Tirzepatide may offer more rapid and significant fat loss than Semaglutide, thanks to its dual-hormone activation

This hormone plays a key role in regulating blood sugar levels, appetite, and digestion

Combined with semaglutide gastric emptying delay, very high fat intake can cause nausea, bloating, and reflux that makes eating feel genuinely unpleasant

Some people may experience no digestive symptoms, while others may need additional support during the first few weeks of treatment