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Estrogens regulate pancreatic -cell insulin biosynthesis, survival, insulin secretion, and expression of GLUT2, the primary glucose sensor and transporter in rodent pancreatic cells (75, 76)

This includes the downregulation of Bax (a pro-apoptotic marker), upregulation of Bcl-2 (an anti-apoptotic protein), and increased expression of proliferating cell nuclear antigen (PCNA), a key marker of cell proliferation [65]

doi: 10.1186/s12935-021-02280-5, 157

Transferrin and ferritin are iron-transporting proteins which also possess antioxidant properties (Loeffler et al

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