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Interestingly, both estradiol and leptin receptors colocalize in kisspeptinergic neurons, which are considered to be the link between nutrition (metabolism) and reproduction (ovulatory function) (151)

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For instance, H7 of GLP-1 forms hydrogen and hydrophobic interactions with TM3 and TM5 residues like Y 241 , I 309 , R 310 , and I 313 , whereas A8 forms hydrophobic interactions with L 384 and L 388 of TM7

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