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This makes combination therapy more effective and improves health outcomes

However, due to B12s effect on the metabolism, it is possible that B12 deficiency could play some part in weight gain, to whatever degree

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impaired fatty acid -oxidation metabolism and impaired branched-chain amino acid metabolism can lead to the accumulation of large amounts of acyl CoA

In multivariate regression analysis including HOMA-IR and total cholesterol within the obese group alone, HOMA-IR remained significantly associated with MOTS-c, demonstrating a curvilinear correlation (Supplementary Table 710, Supplementary Fig.1)