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For example, in cardiovascular disease, type 2 ryanodine receptor (RyR2) constitutes the major intracellular Ca 2+ release channel in atrial myocytes, and oxidative stressinduced dysfunction of this channel alters intracellular Ca 2+ homeostasis, which usually leads to the generation of atrial fibrillation [136]

This marks the first GLP-1 receptor agonist approved for MASH, offering a new therapeutic option for a growing patient population

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The hydrophobic pore could provide an additional layer of substrate discrimination for LPL beyond the previously identified lid peptide and hydrophobic binding pocket

Vegetable magnesium stearate in a nonGMO vegetable capsule composed of vegetable carbohydrate gum and purified water

Competing interests The authors declare that they have no competing interests