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In women with PCOS who have vitamin D deficiencies, co-supplementation of calcium and vitamin D has demonstrated improvements in -cell function, TAC, high-sensitivity C-reactive protein (hs-CRP), and glutathione (GSH) levels [142]

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(N=13) found that isotretinoin reduced brain metabolic activity in the orbitofrontal cortex, a region involved in mood regulation, whereas the antibiotic control group showed no such change

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