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Because of its structural differences, IGF-1 LR3 shows reduced affinity for certain IGF-binding proteins (IGFBPs) in vitro, enabling researchers to study more sustained receptor engagement and downstream signaling under controlled conditions

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Neither compound is FDA-approved for any clinical use

This is typically short-lived and should subside within a few hours after the injection

doi:10.1007/s12602-024-10418-w