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Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

The author MM is also highly thankful to the Ministry of Education and SPD-RUSA Rajasthan for the financial support received under the RUSA-2.0 project

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In the present study, TPH1 null mice were more susceptible than controls to acetaminophen-and NAPQI-induced lipid peroxidation, as evidenced by increased MDA and MPO levels and reduced GSH and GSH-px in the liver tissues which were also important antioxidant enzymes

Another study [54] looking at those with neurodegenerative disorders found that a single intravenous dose of NAC led to an increase of the blood GSH/GSSG ratio and levels of glutathione in the brain

Interestingly, some dietary compounds or lifestyle behaviors may increase endogenous glutathione production