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Any references to potential activity are based on experimental observations and do not indicate medical efficacy

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accordingly, the absence of a stable teratogenic pattern should not be interpreted as proof of safety ( From a practical standpoint, the most defensible position remains planned exposure avoidance: explicit fertility planning, reliable contraception during treatment, label-informed discontinuation before conception attempts, immediate cessation once pregnancy is recognized, and active metabolic maintenance during the washout period to reduce rebound-related gestational risk ( 4.5.1 Post-discontinuation weight rebound and gestational risk Evidence for post-discontinuation weight rebound and related gestational risk is derived predominantly from non-PCOS or mixed-population cohorts rather than from PCOS-specific longitudinal studies

The insulin-producing beta cells begin to wear out, and insulin production declines

Any drug that inhibits CYP3A4 (ketoconazole, clarithromycin, grapefruit juice in large quantities) can raise atorvastatin plasma levels and increase myopathy risk

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