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doi: 10.1210/en.2008-1221 [DOI] [PMC free article] [PubMed] [Google Scholar] 46.Williams DL, Baskin DG, Schwartz MW

Initial Loading Phase Protocol In this first step, patients get B12 shots every day for one to two weeks

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However, given the progressive nature of PD, symptoms tend to worsen despite treatment, and over time, existing therapies begin to lose efficacy, even at increased doses

For hepatic differentiation, a stepwise approach was employed

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