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Therefore, weight regain is common in various weight loss strategies and it is necessary to establish the long-term anti-obesity treatment in clinical practice

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Both substances can cause gastrointestinal symptoms including nausea, vomiting, and diarrhoea, which might potentially intensify when combined

Although inclusion of this dose allows exploration of the upper range of semaglutide exposure, corresponding estimatesparticularly comparisons with higher doses of tirzepatideshould be considered exploratory until additional data become available