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A final pathway that is altered in prostate cancer is nuclear factor kB (NF-kB) signaling pathway, which is correlated with a complex clinical case since it appears to have an important role in the regulation of progression, in the formation of metastases, and also in resistance to therapies [73, 74]

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Plasma GHK-Cu concentrations decline with age, from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60, correlating with reduced skin repair capacity