As the next phase of this research, more sophisticated in vivo models, incorporating chronic injury paradigms, long-term follow-ups, and genetic or pharmacological modifications of inflammatory pathways, will be critical to substantiate the translational potential of this approach
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The extrinsic pathway is mediated by binding of death-inducing ligands such as TNF and Fas ligand that bind to cognate receptors that, in turn, recruit adaptor proteins and pro-caspases, leading to the assembly of the death-inducing signaling complex (DISC) and the activation of effector caspases 75
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Understanding steady state Here is where it gets interesting
(6) The liver and kidneys shape the number further