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With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium

Paschou, S

Annual Review of Pharmacology and Toxicology , 45, 51-88.

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K., & Levkovich Yu, I

This approach has the strongest clinical evidence of the two and is widely used for larger treatment areas such as the abdomen, flanks and thighs