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GLP-1 is produced by enteroendocrine L-cells in the distal ileum and colon
Similar long-term data for oral formulations is currently unavailable
A study of 120 hospitalised children with bronchopneumonia evaluated inhaled NAC versus ambroxol (another mucolytic drug), and found NAC to be superior to ambroxol, with faster recovery, shorter hospital stay and less AEs in the children receiving NAC
P =0.04)
Perhaps most convincingly, rat studies in which plasma glucose and lactate levels were measured in the inferior vena cava, hepatic vein, hepatic portal vein and the aorta demonstrated that the plasma lactate concentration peaks in the hepatic portal vein, with a corresponding drop in the plasma glucose concentration
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