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Subsequent STEP trials (2 through 8) have replicated the effect across different populations and dosing schedules
In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]
Similarly, batch-specific documentation may be hard to trace
10.1016/S0140-6736(24)02317-1 3
[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Sierra, J
Despite this large disease burden, uptake of GLP-1 therapies remains limited
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